According to new research published in the Journal of Biological Chemistry in May 2018, epigallocatechin-3-gallate (EGCG), the primary active constituent found in green tea, may be able to reduce plaque formations in arteries that block blood flow to the heart and brain, reducing the risk of heart attack or stroke.
The anti-inflammatory and antioxidant properties of green tea are well known, but more recent research is focused on the ability of EGCG to counter amyloid plaques in the brain that contribute to Alzheimer’s Disease. Similarly, in people with advanced atherosclerosis that affects heart health, plaque formations are attributed to deposits of a protein called apolipoprotein A-1 (apoA-1). The researchers found that EGCG binds to amyloid fibers of this protein, reducing their molecular size and making them less likely to damage blood vessels.
David Townsend, Eleri Hughes, Geoffrey Akien, Katie L. Stewart, Sheena E. Radford, David Rochester, David A. Middleton. Epigallocatechin-3-gallate remodels apolipoprotein A-I amyloid fibrils into soluble oligomers in the presence of heparin. Journal of Biological Chemistry, 2018